Richard’s 10 guiding principles when developing an antimicrobial
When deciding to find a novel antipathogen, I had to look at the potential answers in a manner that differed from the way than was being followed by established Pharma companies (and their research teams) and also the paths followed by Academia. I, therefore, had to set out the guiding principles that would focus our thinking and activities on the task in hand and the ambition.
Even more remarkably is the essence of how, why, what and where I investigated to establish the technology can be summed up by following these ten principles:
- WE MUST STOP PATHOGENS FROM TAKING OVER THE PLANET: Over the last decade, I have dedicated my efforts to exploring innovative methods for eliminating pathogens in Human health. The incentive came from.
- the ever-growing challenges related to Antibiotic Resistance (ABR), HIV, SEPSIS, and
- COVID, as well as…
- exploring the intricate relationship between the microbiome and mental health.
- so many of our therapies and technologies are losing efficacy or causing severe side-effects and harm
- that my technology can address the very different chemistries in these 3 types of pathogens is truly remarkable, with the potential to bring about substantial improvements in people’s health and overall length and quality of life.
- HUMANS, ANIMALS AND PLANTS ARE MAINTAINED IN POOR HEALTH: THIS HAS TO CHANGE. The United States can be classified as having one of the least effective healthcare systems globally, with recurring instances of old infections and illnesses resurfacing at alarming rates. The country exhibits a relatively low life expectancy, trailing behind numerous low- and middle-income countries (LMICs). Despite this, residents in the U.S. bear significantly higher healthcare costs. Examples like the current near-epidemics of ABR and SEPSIS illustrate this issue, and the handling of COVID represented the pinnacle of what not to do. It’s important to note that the challenges are not unique to the U.S.; much of the Western world faces similar issues and LMICs are blindly following the west’s decisions. The existing methods for combating pathogens in or on our bodies, as well as in the environment, often involve a combination of ineffective approaches or the use of toxic chemicals. Unfortunately, these substances not only target harmful microorganisms but also harm the friendly ones crucial for human and animal health and well-being.
- THE PATIENT’S NEEDS COME FIRST AND SECOND AND THIRD. Destroy the pathogen whilst doing nothing detrimental to the patient.
- WE SHOULD STOP ACCEPTING HEALTHCARE: accept nothing less than HEALTH as our ambition. Health means elimination of the pathogens, that cause the disease or the condition,
- YOU’RE NOT WHAT YOU EAT: YOU ARE WHAT YOU ABSORB from the food you eat: This perspective helps explain the health challenges in the USA and Western countries, attributing poor health to suboptimal food choices, that impact nutrient absorption negatively. The correlation between dietary choices and overall health emphasizes the importance of making informed and nutritious decisions to promote well-being. At long last Health authorities are accepting there is a link between the Quality of our Health and the Quality of our Food and the Quality of Agriculture. Whilst infections and diseases are seen to be affected by these links we can also see an even stronger link with NCDs, especially Mental conditions.
- IT ALL STARTS IN THE GUT – the Microbiome: The health of our microbiome is intricately connected to our diet. The gut microbiome relies on the nutrients we absorb from the food we consume. Choosing the right nutrition is crucial to feeding the gut microbiome appropriately. However, the wrong dietary choices, including excessive consumption of even healthy foods, can lead to dysbiosis.Dysbiosis, resulting from various aspects of our lives, can contribute to poor health, particularly mental health issues, which are on the rise globally. Conditions such as depression, bipolar disorder, ADHD, and autism have been linked to dysbiosis, and there is emerging evidence of a connection between Alzheimer’s and the microbiome. According to some viewpoints, effective relief for individuals dealing with these conditions may not be fully realized until the gut is rebalanced (starting with elimination of the pathogens). This involves a targeted approach to removing pathogenic bacteria while preserving the essential commensal bacteria that are distinct to each individual’s gut microbiome. Then rebuilding the commensal bacteria (the probiotics) that exist in YOUR gut, not just with any probiotics but building those probiotics that are in, or are needed for, YOUR gut. Too much of one or more of the good probiotics can lead to dysbiosis and poor health outcomes. Microbiomes exist everywhere, not just in Humans but also in Animals and also in Plants. We know that Dysbiosis causes many problems for humans and we must look closely at how dysbiosis relates to problems for animals and plants. Then it can be realized how this technology will benefit these other parts of our Planet.
- DIVERSITY AND BALANCE ENABLE STRONGER ACHIEVEMENTS: A Diversity of approach and balance of skills and experience in a team working with determination and clear targets can achieve more and faster than any individual.
- RESTRAINT NOT OVERINDULGENCE: Sufficient is all you need. Greed causes many problems, not just eating too much leading to obesity, but too many antibiotics leading to resistance, grabbing things just to prevent it being available for others.
- RESISTANCE MUST BE AVOIDED : Should our design allow Resistance to be developed by the pathogens, we are no better than existing remedies. We will do better.
- NATURE HAS THE ANSWER: CHEMISTRY IS THE KEY: The molecule in our patent replicates one of the natural mechanisms found in our bodies to combat ingress of pathogens, irrespective of whether they are viral, fungal, or bacterial in nature, while being harmless to commensal bacteria.
Individualized analysis of the gut microbiome is deemed essential, and collaboration with a specific lab that can comprehensively analyze gut microbiota from a stool sample is integral. This analysis can provide insights into the symptoms an individual may be experiencing, and then link the pathogen to the problem. Collaborative efforts then can then bring relief from symptoms and, potentially, cures for diseases involving various mental health issues, including depression, bipolar disorder, ADHD, and autism. While OSCEAUN™ is a crucial product, addressing the complexities of conditions like Alzheimer’s requires a comprehensive approach that includes rebalancing the gut. The hope is that these efforts will contribute to halting one of the most significant killers in the developed world.
Miraculously, the Principles worked well and the achievement far exceeded the simple ambition of a novel antimicrobial for human health. The technology is effective for treating Pathogenic diseases in HUMANS, ANIMALS and PLANTS.
For an understanding of how, by following these Principles for our R+D, we identified, and then developed, our GERM BUSTER techniques click on GERM BUSTERS